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Plos One : Adam17 Mediates Mmp9 Expression in Lung Epithelial Cell...

By: Tianqing Peng

Description : The purposes were to study the role of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-a/nuclear factor-kB (NF-kB) signaling in matrix metalloproteinase 9 (MMP9) expression in A549 cells and to investigate the effects of lentivirusmediated RNAi targeting of the disintegrin and metalloproteinase 17 (ADAM17) gene on LPS-induced MMP9 expression. MMP9 expression induced by LPS in A549 cells was significantly increased in a dose- and time-dependent ...

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Plos One : Chronic Treatment with the Glp1 Analogue Liraglutide In...

By: Javier Vitorica

Description : Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer’s patients, along with age, the presence of Ab in the brain inhibits this process by reducing stem cell proliferation and cell differentiation. GLP-1 is a growth factor that has neuroprotective properties. GLP1 receptors are present on neuronal progenitor cells, and the GLP-1 analogue liraglutide has been shown to increase cell prolif...

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Plos One : Native MacRophyte Density and Richness Affect the Invas...

By: Jordi Moya-larano

Description : The role of the native species richness and density in ecosystem invasibility is a matter of concern for both ecologists and managers. We tested the hypothesis that the invasiveness of Urochloa arrecta (non-native in the Neotropics) is negatively affected by the species richness and abundance of native aquatic macrophytes in freshwater ecosystems. We first created four levels of macrophyte richness in a greenhouse (richness experiment), and we then manipula...

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Plos One : the Prolyl Isomerase Pin1 Acts Synergistically with Cdk...

By: Karin Dahlman-wright

Description : In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over three decades due to the fact that they elicit cell cycle arrest. Unfortunately, after an initial period, most cells become resistant to hormonal therapy. Peptidylprolyl isomerase 1 (Pin1), a protein overex...

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Plos One : Functional Haplotypes of the Htert Gene, Leukocyte Telo...

By: Yiqing Song

Description : The associations between the functional haplotype of hTERT gene and telomere length and the risk of atherosclerotic PAD suggested that mean leukocyte telomere length may independently serve as a potential predictor of PAD.

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Plos One : Glutamate Receptor Subunit and Calmodulin Kinase II Exp...

By: Anthony E. Kline

Description : For the 24 h, 72 h, 1 week and 1 month data, there was no significant effect of surgery for any hippocampal subregion. However, for the 6 month data set, T maze training had a significant effect independently of surgery. The results of these experiments suggest that BVD is not associated with large changes in glutamate receptor subunit or CaMKIIa expression in the rat hippocampus, at least in terms of both the intra-cytoplasmic and membrane receptor subunit...

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Plos One : Development of in Vitro 3D Tissueflex® Islet Model for ...

By: Bridget Wagner

Description : Increasing individuals diagnosed with type II diabetes pose a strong demand for the development of more effective anti-diabetic drugs. However, expensive, ethically controversial animal-based screening for anti-diabetic compounds is not always predictive of the human response. The use of in vitro cell-based models in research presents obviously ethical and cost advantages over in vivo models. This study was to develop an in vitro three-dimensional (3D) perf...

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Plos One : Vegf Receptor Blockade Markedly Reduces Retinal Microgl...

By: Michael E. Boulton

Description : Although blocking VEGF has a positive effect in wet age-related macular degeneration (AMD), the effect of blocking its receptors remains unclear. This was an investigation of the effect of VEGF receptor (VEGFR) 1 and/or 2 blockade on retinal microglia/macrophage infiltration in laser-induced choroidal neovascularization (CNV), a model of wet AMD. CNV lesions were isolated by laser capture microdissection at 3, 7, and 14 days after laser and analyzed by RT-P...

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Plos One : Phylogenetics and Differentiation of Salmonella Newport...

By: Paul J. Planet

Description : Salmonella Newport has ranked in the top three Salmonella serotypes associated with foodborne outbreaks from 1995 to 2011 in the United States. In the current study, we selected 26 S. Newport strains isolated from diverse sources and geographic locations and then conducted 454 shotgun pyrosequencing procedures to obtain 16–24 6coverage of high quality draft genomes for each strain. Comparative genomic analysis of 28 S. Newport strains (including 2 reference...

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Plos One : H2S-releasing Aspirin Protects Against Aspirin-induced ...

By: Peiwen Fei

Description : The aim of this study was to examine the effect of ACS14, a hydrogen sulfide (H2S)-releasing derivative of aspirin (Asp), on Asp-induced gastric injury. Gastric hemorrhagic lesions were induced by intragastric administration of Asp (200 mg/kg, suspended in 0.5% carboxymethyl cellulose solutions) in a volume of 1 ml/100 g body weight. ACS14 (1, 5 or 10 mg/kg) was given 30 min before the Asp administration. The total area of gastric erosions, H2S concentratio...

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Plos One : Association Between Serum Ferritin Levels and Risk of t...

By: James R. Connor

Description : Ferritin is a ubiquitous intracellular protein that can store and release iron and act as a buffer against iron deficiency and iron overload. Ferritin is widely used as a clinical biomarker to evaluate iron status. Increased serum ferritin concentrations have been reported to be associated with metabolic syndrome (MetS) features. However, serum ferritin concentrations differ significantly according to sex and ethnicity, and the data concerning the relations...

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Plos One : Quantifying Morphological Parameters of the Terminal Br...

By: Henrik Watz

Description : An effective technique of phase contrast synchrotron radiation computed tomography was established for the quantitative analysis of the microstructures in the respiratory zone of a mouse lung. Heitzman’s method was adopted for the whole-lung sample preparation, and Canny’s edge detector was used for locating the air-tissue boundaries. This technique revealed detailed morphology of the respiratory zone components, including terminal bronchioles and alveolar ...

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Plos One : Circulating Micrornas in Patients with Shiga-toxin- Pro...

By: Alma Zernecke

Description : Circulating microRNAs are strongly altered in this patient cohort and associated with neurological symptoms as well as platelet count.

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Plos One : the Involvement of Thaumatin-like Proteins in Plant Foo...

By: Bin Xue

Description : Cross-reactivity of plant foods is an important phenomenon in allergy, with geographical variations with respect to the number and prevalence of the allergens involved in this process, whose complexity requires detailed studies. We have addressed the role of thaumatin-like proteins (TLPs) in cross-reactivity between fruit and pollen allergies. A representative panel of 16 purified TLPs was printed onto an allergen microarray. The proteins selected belonged ...

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Plos One : Egfr Gene Copy Number as a Prognostic Marker in Colorec...

By: Jian-xin Gao

Description : Among the anti-EGFR-treated patients, increased EGFR GCN appears to be associated with improved survival outcomes. The effect on survival appears to be related to patients receiving the line of treatment.

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Plos One : Sorl1is Genetically Associated with Late-onset Alzheime...

By: Mathias Toft

Description : To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations : Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide signi...

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Plos One : Wide Variation in Virulence and Genetic Diversity of Bi...

By: Nicole M. Gerardo

Description : Strawberry (Fragaria6ananassa) is one of the most important berry crops in the world. Root rot of strawberry caused by Rhizoctonia spp. is a serious threat to commercial strawberry production worldwide. However, there is no information on the genetic diversity and phylogenetic status of Rhizoctonia spp. associated with root rot of strawberry in Australia. To address this, a total of 96 Rhizoctonia spp. isolates recovered from diseased strawberry plants in W...

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Plos One : Biochemical and Biophysical Properties of Interactions ...

By: Mark J. Van Raaij

Description : Peripheral stalk subunits of eukaryotic or mammalian vacuolar ATPases (V-ATPases) play key roles in regulating its assembly and disassembly. In a previous study, we purified several subunits and their isoforms of the peripheral stalk region of Homo sapiens (human) V-ATPase: such as C1, E1G1, H, and the N-terminal cytoplasmic region of Vo, a1. Here, we investigated the in vitro binding interactions of the subunits at the stalk region and measured their speci...

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Plos One : Mechanism of Intramembrane Cleavage of Alcadeins by Γ-s...

By: Stephen D. Ginsberg

Description : The initial e-site position does not always determine the final c-cleavage position in Alcs, which differed from APP. No additional c-cleavage sites are generated from artificial/non-physiological positions of e-cleavage for Alcs, while the artificial e-cleavage positions can influence in selection of physiological c-site positions. Because alteration of c-secretase activity is thought to be a pathogenesis of sporadic Alzheimer’s disease, Alcs are useful an...

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Plos One : the Distribution of Fruit and Seed Toxicity During Deve...

By: Joanna E. Lambert

Description : Secondary compounds in fruit mediate interactions with natural enemies and seed dispersers, influencing plant survival and species distributions. The functions of secondary metabolites in plant defenses have been well-studied in green tissues, but not in reproductive structures of plants. In this study, the distribution of toxicity within plants was quantified and its influence on seed survival was determined in Central Panama. To investigate patterns of al...

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