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Chocolate for Anne Frank (English)

By: Machiel van der Stelt; translated by Machiel van der Stelt

Anne and the others living in the secret annex in Amsterdam, are betrayed and on the fourth of August nineteen forty four arrested. The members are sent to different concentration camps. Anne and her older sister Margot end up in the Bergen Belsen Camp. Anne is expecting terrible circumstances but when she gets involved with SS guard Adolfo, her situation might change from despair to hope. In this tragic and disturbing story you will discover that inhumane and murderous behaviour of people can reach extreme levels during war. Because of recurring wars we have to ask ourselves if humankind is ever capable of creating a peaceful and free society? Warning: this story is not recommended for children younger than twelve years old, because of confronting or graphic scenes and events....

Chocolate for Anne Frank Postface

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Plos One : Gene Expression Networks Underlying Ovarian Development in Wild Largemouth Bass Micropterus Salmoides, Volume 8

By: S. Nicholas Foulkes

Description : This study offers novel insight into the gene networks underlying vitellogenesis, ovulation and atresia and generates new hypotheses about the cellular pathways regulating oocyte maturation....

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Rudin a Novel

By: Ivan S. Turgenev

Excerpt: Rudin by Ivan Turgenev, translated by Constance Garnett.

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Plos One : Lactobacillus Reuteri Dsm 17938 Changes the Frequency of Foxp3+ Regulatory T Cells in the Intestine and Mesenteric Lymph Node in Experimental Necrotizing Enterocolitis, Volume 7

By: Valli De Re

Description : Necrotizing enterocolitis (NEC) is an inflammatory disease of the intestine in premature infants. Lactobacillus reuteri DSM 17938 improves survival and reduces the incidence and severity of NEC in a rodent model. Foxp3+ regulatory T cells (Tregs) maintain intestinal homeostasis by controlling inflammation and inducing tolerance. To determine whether there are insufficient numbers of Tregs to control inflammation in NEC and to determine if LR17938 increases the frequency of Tregs, we studied selected groups of newborn Sprague-Dawley rats according to feeding plan : dam6LR17938, formula6LR17938, and NEC6LR17938. NEC was induced by gavage feeding with special formula and exposure to hypoxic conditions. Lymphocytes isolated from ileum, mesenteric lymph nodes (MLN), spleen and thymus were labeled for T cell surface markers (CD3, CD4, CD8) and intracellular Foxp3: and labeled cells were analyzed by flow cytometry. The percentage of CD3+ T cells and Foxp3+ Tregs in the ileum significantly decreased in pups with NEC, compared to normal controls. Feeding LR17938 to neonatal rats with NEC increased the % of Foxp3+ T cells in the...

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Vanity Fair

By: William Makepeace Thackeray

Excerpt: Vanity Fair by William Makepeace Thackeray.

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Plos Pathogens : Acquisition of Drug Resistance and Dependence by Prions, Volume 9

By: David Westaway

Description : We have reported that properties of prion strains may change when propagated in different environments. For example, when swainsonine-sensitive 22L prions were propagated in PK1 cells in the presence of swainsonine, drug-resistant variants emerged. We proposed that prions constitute quasi- populations comprising a range of variants with different properties, from which the fittest are selected in a particular environment. Prion populations developed heterogeneity even after biological cloning, indicating that during propagation mutation-like processes occur at the conformational level. Because brain-derived 22L prions are naturally swainsonine resistant, it was not too surprising that prions which had become swa sensitive after propagation in cells could revert to drug resistance. Because RML prions, both after propagation in brain or in PK1 cells, are swainsonine sensitive, we investigated whether it was nonetheless possible to select swainsonine-resistant variants by propagation in the presence of the drug. Interestingly, this was not possible with the standard line of PK1 cells, but in certain PK1 sublines not only ...

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Twelfth Night or What You Will

By: William Shakespeare

Excerpt: Twelfth Night or What You Will.

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Plos One : Angiopoietin-2 is Critical for Cytokine-induced Vascular Leakage, Volume 8

By: Samir M. Parikh

Description : Genetic experiments (loss-of-function and gain-of-function) have established the role of Angiopoietin/Tie ligand/receptor tyrosine kinase system as a regulator of vessel maturation and quiescence. Angiopoietin-2 (Ang-2) acts on Tie2-expressing resting endothelial cells as an antagonistic ligand to negatively interfere with the vessel stabilizing effects of constitutive Ang-1/Tie-2 signaling. Ang-2 thereby controls the vascular response to inflammation-inducing as well as angiogenesisinducing cytokines. This study was aimed at assessing the role of Ang-2 as an autocrine (i.e. endothelial-derived) regulator of rapid vascular responses (within minutes) caused by permeability-inducing agents. Employing two independent in vivo assays to quantitatively assess vascular leakage (tracheal microsphere assay, 1–5 min and Miles assay, 20 min), the immediate vascular response to histamine, bradykinin and VEGF was analyzed in Ang-2-deficient (Ang-22/2) mice. In comparison to the wild type control mice, the Ang22/2 mice demonstrated a significantly attenuated response. The Ang- 22/2 phenotype was rescued by systemic administration (p...

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The Odyssey of Homer

By: Pope, Alexander, 1688-1744

INTRODUCTION: Scepticism is as much the result of knowledge, as knowledge is of scepticism. To be content with what we at present know, is, for the most part, to shut our ears against conviction; since, from the very gradual character of our education, we must continually forget, and emancipate ourselves from, knowledge previously acquired; we must set aside old notions and embrace fresh ones; and, as we learn, we must be daily unlearning something which it has cost us no small labour and anxiety to acquire....

· INTRODUCTION · THE ODYSSEY OF HOMER · BOOK I. MINERVA'S DESCENT TO ITHACA. · BOOK II. THE COUNCIL OF ITHACA. · BOOK III. THE INTERVIEW OF TELEMACHUS AND NESTOR. · BOOK IV. THE CONFERENCE WITH MENELAUS. · BOOK V. THE DEPARTURE OF ULYSSES FROM CALYPSO · BOOK VI. · BOOK VII. THE COURT OF ALCINOUS. · BOOK VIII. · BOOK IX. THE ADVENTURES OF THE CICONS, LOTOPHAGI AND CYCLOPS · BOOK X. ADVENTURES WITH AEOLUS, THE LAESTRYGONS, AND CIRCE. · BOOK XI. THE DESCENT INTO HELL. · BOOK XII. THE SIRENE, SCYLLA, AND CHARYBDIS. · BOOK XIII. THE ARRIVAL OF ULYSSES IN ITHACA. · BOOK XIV. THE CONVERSATION WITH EUMAEUS. · BOOK XV. THE RETURN OF TELEMACHUS. · BOOK XVI. THE DISCOVERY OF ULYSSES TO TELEMACHUS. · BOOK XVII. · BOOK XVIII. THE FIGHT OF ULYSSES AND IRUS. · BOOK XIX. THE DISCOVERY OF ULYSSES TO EURYCLEA. · BOOK XX. · BOOK XXI. THE BENDING OF ULYSSES' BOW. · BOOK XXII. THE DEATH OF THE SUITORS. · BOOK XXIII. · BOOK XXIV....

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Plos Pathogens : Molecular Cloning and Characterization of Novel Glutamate-gated Chloride Channel Subunits from Schistosoma Mansoni, Volume 9

By: Martin Richard
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Rupert of Hentzau from the Memoirs of Fritz Von Tarlenheim Sequel to the Prisoner of Zenda

By: Anthony Hope

A man who has lived in the world, marking how every act, although in itself perhaps light and insignificant, may become the source of consequences that spread far and wide, and flow for years or centuries, could scarcely feel secure in reckoning that with the death of the Duke of Strelsau and the restoration of King Rudolf to liberty and his throne, there would end, for good and all, the troubles born of Black Michael's daring conspiracy. The stakes had been high, the struggle keen; the edge of passion had been sharpened, and the seeds of enmity sown. Yet Michael, having struck for the crown, had paid for the blow with his life: should there not then be an end? Michael was dead, the Princess her cousin's wife, the story in safe keeping, and Mr. Rassendyll's face seen no more in Ruritania. Should there not then be an end? So said I to my friend the Constable of Zenda, as we talked by the bedside of Marshal Strakencz. The old man, already nearing the death that soon after robbed us of his aid and counsel, bowed his head in assent: in the aged and ailing the love of peace breeds hope of it. But Colonel Sapt tugged at his gray moustache...

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Plos One : Both Lethal and Edema Toxins of Bacillus Anthracis Disrupt the Human Dendritic Cell Chemokine Network, Volume 7

By: Prosper N. Boyaka

Description : Bacillus anthracis, the agent of anthrax, produces two main virulence factors : a capsule and two toxins. Both lethal toxin (LT) and edema toxin (ET) paralyze the immune defense system. Here, we analyze the effects of LT and ET on the capacity of human monocyte-derived dendritic cells (MoDC) to produce proinflammatory chemokines. We show that both toxins disrupt proinflammatory chemokine production. LT has more pronounced effects than ET on CXCL8 production, which is correlated with impaired recruitment of neutrophils in vitro. Finally, we show that both toxins also differentially disrupt IL- 12p70, IL-10, and TNF-a production. Taken together, these results demonstrate that both B. anthracis toxins alter MoDC functions and the activation of the innate immune system....

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The Love

CONTENTS: Chapter 1: The University of Life. -- Chapter 2: Light and energy. -- Chapter 3: Evolution. -- Chapter 4: Our history. -- Chapter 5: The wheels of humanity. -- Chapter 6: Religion. -- Chapter 7: Spirituality and ambitions of the soul. -- Chapter 8: Clash of the realms. -- Chapter 9: Saints. -- Chapter 10: Connectivity and the cognitive functioning of the mind. -- Chapter 11: Dimensions and meridians. -- Chapter 12: Circulation and well being. -- Chapter 13: All of the answers are within. -- Chapter 14: The body. -- Chapter 15: Stem cell production. -- Chapter 16: Molecular anatomical structure. -- Chapter 17: Spectroscope analysis. -- Chapter 18: Acid is the key to the next millennium. -- Chapter 19: Natural quotient. -- Chapter 20: Regeneration....

CONTENTS Chapter 1: The University of Life. Chapter 2: Light and energy. Chapter 3: Evolution. Chapter 4: Our history. Chapter 5: The wheels of humanity. Chapter 6: Religion. Chapter 7: Spirituality and ambitions of the soul. Chapter 8: Clash of the realms. Chapter 9: Saints. Chapter 10: Connectivity and the cognitive functioning of the mind. Chapter 11: Dimensions and meridians. Chapter 12: Circulation and well being. Chapter 13: All of the answers are within. Chapter 14: The body. Chapter 15: Stem cell production. Chapter 16: Molecular anatomical structure. Chapter 17: Spectroscope analysis. Chapter 18: Acid is the key to the next millennium. Chapter 19: Natural quotient. Chapter 20: Regeneration....

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Plos One : Human Umbilical Cord Blood Mononuclear Cells in a Double-hit Model of Bronchopulmonary Dysplasia in Neonatal Mice, Volume 8

By: Saverio Bellusci

Description : The results of our study demonstrate the therapeutic potential of umbilical cord blood MNCs in a new double-hit model of BPD in newborn mice. We found improved lung structure and effects on molecular level. Further studies are needed to address the role of systemic administration of MNCs in experimental BPD....

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Our Mutual Friend

By: Charles Dickens

Excerpt: In these times of ours, though concerning the exact year there is no need to be precise, a boat of dirty and disreputable appearance, with two figures in it, floated on the Thames, between Southwark bridge which is of iron, and London Bridge which is of stone, as an autumn evening was closing in....

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Plos One : Demonstration of Cytotoxicity Against Wasps by Pierisin-1 ; a Possible Defense Factor in the Cabbage White Butterfly, Volume 8

By: N. Vladimir Uversky

Description : The cabbage white butterfly, Pieris rapae, produces pierisin-1, a protein inducing apoptosis of mammalian cells. In the present study, the biological activity of pierisin-1 as a protective agent against parasitic wasps for P. rapae was examined. Pierisin-1 caused detrimental effects on eggs and larvae of non-habitual parasitoids for P. rapae, Glyptapanteles pallipes, Cotesia kariyai and Cotesia plutellae at 1–100 mg/ml, levels essentially equivalent to those found in P. rapae larvae. In contrast, eggs and larvae of the natural parasitoid of P. rapae, Cotesia glomerata proved resistant to the toxicity of pierisin-1 through inhibition of pierisin-1 penetration of the surface layer. The expression level of pierisin-1 mRNA in the larvae of P. rapae was increased by parasitization by C. plutellae, whereas it was decreased by C. glomerata. In addition, C. plutellae was associated with elevation of activated pierisin-1 in the hemolymph. From these observations, it is suggested that pierisin-1 could contribute as a defense factor against parasitization by some type of wasps in P. rapae....

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Bram Stoker's Dracula

By: Bram Stoker

Excerpt: Buda-Pesth seems a wonderful place, from the glimpse which I got of it from the train and the little I could walk through the streets. I feared to go very far from the station, as we had arrived late and would start as near the correct time as possible....

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Plos One : Functional Complementation of a Model Target to Study Vpu Sensitivity, Volume 8

By: Michael Schindler

Description : HIV-1 forms infectious particles with Murine Leukemia virus (MLV) Env, but not with the closely related Gibbon ape Leukemia Virus (GaLV) Env. We have determined that the incompatibility between HIV-1 and GaLV Env is primarily caused by the HIV-1 accessory protein Vpu, which prevents GaLV Env from being incorporated into particles. We have characterized the ‘Vpu sensitivity sequence’ in the cytoplasmic tail domain (CTD) of GaLV Env using a chimeric MLV Env with the GaLV Env CTD (MLV/GaLV Env). Vpu sensitivity is dependent on an alpha helix with a positively charged face containing at least one Lysine. In the present study, we utilized functional complementation to address whether all the three helices in the CTD of an Env trimer have to contain the Vpu sensitivity motif for the trimer to be modulated by Vpu. Taking advantage of the functional complementation of the binding defective (D84K) and fusion defective (L493V) MLV and MLV/GaLV Env mutants, we were able to assay the activity of mixed trimers containing both MLV and GaLV CTDs. Mixed trimers containing both MLV and GaLV CTDs were functionally active and remained se...

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The Blue Lagoon : A Romance

By: H. de Vere Stacpoole

Introduction: Born on April 9, 1863, in Kingstown, Ireland, Henry de Vere Stacpoole grew up in a household dominated by his mother and three older sisters. William C. Stacpoole, a doctor of divinity from Trinity College and headmaster of Kingstown school, died some time before his son's eighth birthday, leaving the responsibility of supporting the family to his Canadian-born wife, Charlotte Augusta Mountjoy Stacpoole. At a young age, Charlotte had been led out of the Canadian backwoods by her widowed mother and taken to Ireland, where their relatives lived. This experience had strengthened her character and prepared her for single parenthood....

· Introduction · BOOK I · PART I · CHAPTER I. WHERE THE SLUSH LAMP BURNS · CHAPTER II. UNDER THE STARS · CHAPTER III. THE SHADOW AND THE FIRE · CHAPTER IV. AND LIKE A DREAM DISSOLVED · CHAPTER V. VOICES HEARD IN THE MIST · CHAPTER VI. DAWN ON A WIDE, WIDE SEA · CHAPTER VII. STORY OF THE PIG AND THE BILLY-GOAT · CHAPTER VIII. S-H-E-N-A-N-D-O-A-H · CHAPTER IX. SHADOWS IN THE MOONLIGHT · CHAPTER X. THE TRAGEDY OF THE BOATS · PART II · CHAPTER XI. THE ISLAND · CHAPTER XII. THE LAKE OF AZURE · CHAPTER XIII. DEATH VEILED WITH LICHEN · CHAPTER XIV. ECHOES OF FAIRY-LAND · CHAPTER XV. FAIR PICTURES IN THE BLUE · PART III · CHAPTER XVI. THE POETRY OF LEARNING...

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Plos Pathogens : Structural Basis of Hcv Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape, Volume 9

By: Michael S. Diamond

Description : The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability. Antibodies targeting these epitopes are resistant to viral escape from neutralization and understanding their binding-mode is important for vaccine design. Human monoclonal antibodies HC84-1 and HC84-27 target conformational epitopes overlapping the CD81 receptor-binding site, formed by segments aa434–446 and aa610–619 within the major HCV glycoprotein E2. No neutralization escape was yet observed for these antibodies. We report here the crystal structures of their Fab fragments in complex with a synthetic peptide comprising aa434–446. The structures show that the peptide adopts an a-helical conformation with the main contact residues F442 and Y443 forming a hydrophobic protrusion. The peptide retained its conformation in both complexes, independently of crystal packing, indicating that it reflects a surface feature of the folded glycoprotein that is exposed similarly on the virion. The same residues of E2 are also i...

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Great Expectations

By: Charles Dickens

Excerpt: Chapter 1. My father?s family name being Pirrip, and my Christian name Philip, my infant tongue could make of both names nothing longer or more explicit than Pip. So, I called myself Pip, and came to be called Pip....

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Plos One : Sdg2-mediated H3K4 Methylation is Required for Proper Arabidopsis Root Growth and Development, Volume 7

By: Yuehui He

Description : Trithorax group (TrxG) proteins are evolutionarily conserved in eukaryotes and play critical roles in transcriptional activation via deposition of histone H3 lysine 4 trimethylation (H3K4me3) in chromatin. Several Arabidopsis TrxG members have been characterized, and among them SET DOMAIN GROUP 2 (SDG2) has been shown to be necessary for global genome-wide H3K4me3 deposition. Although pleiotropic phenotypes have been uncovered in the sdg2 mutants, SDG2 function in the regulation of stem cell activity has remained largely unclear. Here, we investigate the sdg2 mutant root phenotype and demonstrate that SDG2 is required for primary root stem cell niche (SCN) maintenance as well as for lateral root SCN establishment. Loss of SDG2 results in drastically reduced H3K4me3 levels in root SCN and differentiated cells and causes the loss of auxin gradient maximum in the root quiescent centre. Elevated DNA damage is detected in the sdg2 mutant, suggesting that impaired genome integrity may also have challenged the stem cell activity. Genetic interaction analysis reveals that SDG2 and CHROMATIN ASSEMBLY FACTOR-1 act synergisticall...

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Little Wars

By: Herbert George Wells

LITTLE WARS is the game of kings—for players in an inferior social position. It can be played by boys of every age from twelve to one hundred and fifty—and even later if the limbs remain sufficiently supple—by girls of the better sort, and by a few rare and gifted women. This is to be a full History of Little Wars from its recorded and authenticated beginning until the present time, an account of how to make little warfare, and hints of the most priceless sort for the recumbent strategist. But first let it be noted in passing that there were prehistoric Little Wars. This is no new thing, no crude novelty; but a thing tested by time, ancient and ripe in its essentials for all its perennial freshness—like spring. There was a Someone who fought Little Wars in the days of Queen Anne; a garden Napoleon. His game was inaccurately observed and insufficiently recorded by Laurence Sterne. It is clear that Uncle Toby and Corporal Trim were playing Little Wars on a scale and with an elaboration exceeding even the richness and beauty of the contemporary game. But the curtain is drawn back only to tantalise us. It is scarcely conceivable that an...

· I. OF THE LEGENDARY PAST · II. THE BEGINNINGS OF MODERN LITTLE WARFARE · III. THE RULES · IV. THE BATTLE OF HOOK'S FARM · V. EXTENSIONS AND AMPLIFICATIONS OF LITTLE WAR · VI. ENDING WITH A SORT OF CHALLENGE · APPENDIX. LITTLE WARS AND KRIEGSPIEL...

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Ionospheric Composition Measurement by Eiscat Using a Global Fit Procedure : Volume 14, Issue 12 (30/11/-0001)

By: W. Kofman; B. Cabrit

Description: CEPHAG ENSIEG, URA 346 CNRS, Grenoble, France. The aim of this paper is to show the gain of the global fit procedure compared to the classical gate-by-gate analysis in the simultaneous determination of the temperatures and composition profiles in the lower F region. A method for the evaluation of the transition altitude and the width of the transition region between molecular and atomic ions is described in the case of the EISCAT CP1 experiment; it is validated using a simulated experiment. It is shown that alternating-code gates have to be processed together with the long-pulse gates. Our new method is applied on six days of actual data. The results obtained during quiet periods are compared with independent estimations....

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Voyage of the Beagle, The

By: Charles Darwin

The book, also known as Darwin's Journal of Researches, is a vivid and exciting travel memoir as well as a detailed scientific field journal covering biology, geology, and anthropology that demonstrates Darwin's keen powers of observation, written at a time when Western Europeans were still discovering and exploring much of the rest of the world. Although Darwin revisited some areas during the expedition, for clarity the chapters of the book are ordered by reference to places and locations rather than chronologically. With hindsight, ideas which Darwin would later develop into his theory of evolution by natural selection are hinted at in his notes and in the book (Summary from Wikipedia)....

Science, Travel

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Plos One : Microrna 142-3P Mediates Post-transcriptional Regulation of D1 Dopamine Receptor Expression Krishna, Volume 7

By: Erik C. Johnson

Description : The D1 dopamine receptor subtype is expressed in the brain, kidney and lymphocytes. D1 receptor function has been extensively studied and the receptor has been shown to modulate a wide range of physiological functions and behaviors. The expression of D1 receptor is known to change during development, disease states and chronic treatment: however, the molecular mechanisms that mediate the changes in D1 receptor expression under these circumstances are not well understood. While previous studies have identified extracellular factors and signaling mechanisms regulating the transcription of D1 receptor gene, very little is known about other regulatory mechanisms that modulate the expression of the D1 receptor gene. Here we report that the D1 receptor is post-transcriptionally regulated during postnatal mouse brain development and in the mouse CAD catecholaminergic neuronal cell line. We demonstrate that this post-transcriptional regulation is mediated by a molecular mechanism involving noncoding RNA. We show that the 1277 bp 39untranslated region of D1 receptor mRNA is necessary and sufficient for mediating the post-transc...

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The Works of Aristotle

By: Aristotle

Excerpt: The Famous Philosopher. Containing his Complete Masterpiece and Family Physician; his Experienced Midwife, his Book of Problems and his Remarks on Physiognomy...

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Handbook of Physiology

By: Kirkes, William Senhouse, 1823-1864

Description: At head of title: Kirkes' Hand-book of physiology

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The Movements and Habits of Climbing Plants

By: Charles Darwin

This Essay first appeared in the ninth volume of the 'Journal of the Linnean Society,' published in 1865. It is here reproduced in a corrected and, I hope, clearer form, with some additional facts. The illustrations were drawn by my son, George Darwin. Fritz Muller, after the publication of my paper, sent to the Linnean Society (Journal, vol. ix., p. 344) some interesting observations on the climbing plants of South Brazil, to which I shall frequently refer. Recently two important memoirs, chiefly on the difference in growth between the upper and lower sides of tendrils, and on the mechanism of the movements of twining-plants, by Dr. Hugo de Vries, have appeared in the 'Arbeiten des Botanischen Instituts in Wurzburg,' Heft. iii., 1873. These memoirs ought to be carefully studied by every one interested in the subject, as I can here give only references to the more important points. This excellent observer, as well as Professor Sachs, {1} attributes all the movements of tendrils to rapid growth along one side; but, from reasons assigned towards the close of my fourth chapter, I cannot persuade myself that this holds good with respect...

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Lehrbuch Der Physiologie Für Akademische Vorlesungen Und Zum Selbstudium

By: Wagner, Rudolph, 1805-1864

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The Movements and Habits of Climbing Plants

By: Charles Darwin

Excerpt: This Essay first appeared in the ninth volume of the ?Journal of the Linnean Society,? published in 1865. It is here reproduced in a corrected and, I hope, clearer form, with some additional facts. The illustrations were drawn by my son, George Darwin. Fritz Muller, after the publication of my paper, sent to the Linnean Society (Journal, vol. ix., p. 344) some interesting observations on the climbing plants of South Brazil, to which I shall frequently refer. Recently two important memoirs, chiefly on the difference in growth between the upper and lower sides of tendrils, and on the mechanism of the movements of twining?plants, by Dr. Hugo de Vries, have appeared in the ?Arbeiten des Botanischen Instituts in Wurzburg,? Heft. iii., 1873. These memoirs ought to be carefully studied by every one interested in the subject, as I can here give only references to the more important points. This excellent observer, as well as Professor Sachs, {1} attributes all the movements of tendrils to rapid growth along one side; but, from reasons assigned towards the close of my fourth chapter, I cannot persuade myself that this holds good wit...

Table of Contents: The Movements and Habits of Climbing Plants, 1 -- Charles Darwin, 1 -- Preface, 1 -- Chapter I. -- TWINING PLANTS, 2 -- Chapter II. -- LEAF?CLIMBERS, 16 -- Chapter III. -- TENDRIL?BEARERS, 28 -- Chapter IV. -- TENDRIL?BEARERS -- (continued), 40 -- Chapter V. -- HOOK AND ROOT?CLIMBERS. -- CONCLUDING REMARKS, 56...

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Plos One : C-reactive Protein, Volume 8

By: F. I. Jorge Salluh

Description : Residual inflammation at ICU discharge assessed using the CRP/albumin ratio is an independent risk factor for mortality at 90 days in septic patients. The use of the CRP/albumin ratio as a long-term marker of prognosis provides more consistent results than standard CRP values alone....

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Geological Observations on Volcanic Islands

By: Charles Darwin

Although in some respects more technical in their subjects and style than Darwin's Journal, the books here reprinted will never lose their value and interest for the originality of the observations they contain. Many parts of them are admirably adapted for giving an insight into problems regarding the structure and changes of the earth's surface, and in fact they form a charming introduction to physical geology and physiography in their application to special domains. The books themselves cannot be obtained for many times the price of the present volume, and both the general reader, who desires to know more of Darwin's work, and the student of geology, who naturally wishes to know how a master mind reasoned on most important geological subjects, will be glad of the opportunity of possessing them in a convenient and cheap form....

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Plos One : Phosphorylation of Mrna Decapping Protein Dcp1A by the Erk Signaling Pathway During Early Differentiation of 3T3-l1 Preadipocytes, Volume 8

By: Georg Stoecklin

Description : Our findings suggest that ERK-phosphorylated Dcp1a enhances its interaction with the decapping enzyme Dcp2 during early differentiation of 3T3-L1 cells...

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Geological Observations on Volcanic Islandsq

By: Charles Darwin

Excerpt: Although in some respects more technical in their subjects and style than Darwin?s ?Journal,? the books here reprinted will never lose their value and interest for the originality of the observations they contain. Many parts of them are admirably adapted for giving an insight into problems regarding the structure and changes of the earth?s surface, and in fact they form a charming introduction to physical geology and physiography in their application to special domains. The books themselves cannot be obtained for many times the price of the present volume, and both the general reader, who desires to know more of Darwin?s work, and the student of geology, who naturally wishes to know how a master mind reasoned on most important geological subjects, will be glad of the opportunity of possessing them in a convenient and cheap form....

Table of Contents: Geological Observations On Volcanic Islands, 1 -- Charles Darwin, 1 -- EDITORIAL NOTE, 1 -- CRITICAL Introduction, 1 -- Chapter I. -- ST. JAGO, IN THE CAPE DE VERDE ARCHIPELAGO, 6 -- Chapter II. -- FERNANDO NORONHA; TERCEIRA; TAHITI, ETC, 15 -- Chapter III. -- ASCENSION, 20 -- Chapter IV. -- ST. HELENA, 37 -- Chapter V. -- GALAPAGOS ARCHIPELAGO, 48 -- Chapter VI. -- TRACHYTE AND BASALT. -- DISTRIBUTION OF VOLCANIC ISLES, 57 -- Chapter VII. -- AUSTRALIA; NEW ZEALAND; CAPE OF GOOD HOPE, 62...

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Plos One : Listeria Monocytogenes Alters Mast Cell Phenotype, Mediator and Osteopontin Secretion in a Listeriolysin- Dependent Manner, Volume 8

By: Jagadeesh Bayry

Description : Whilst mast cells participate in the immune defence against the intracellular bacterium Listeria monocytogenes, there is conflicting evidence regarding the ability of L. monocytogenes to infect mast cells. It is known that the pore-forming toxin listeriolysin (LLO) is important for mast cell activation, degranulation and the release of pro-inflammatory cytokines. Mast cells, however, are a potential source of a wide range of cytokines, chemokines and other mediators including osteopontin, which contributes to the clearing of L. monocytogenes infections in vivo, although its source is unknown. We therefore aimed to resolve the controversy of mast cell infection by L. monocytogenes and investigated the extent of mediator release in response to the bacterium. In this paper we show that the infection of bone marrow-derived mast cells by L. monocytogenes is inefficient and LLO-independent. LLO, however, is required for calcium-independent mast cell degranulation as well as for the transient and selective downregulation of cell surface CD117 (c-kit) on mast cells. We demonstrate that in addition to the key pro-inflammatory c...

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The Structure and Distribution of Coral Reefs

By: Charles Darwin

Although in some respects more technical in their subjects and style than Darwin's Journal, the books here reprinted will never lose their value and interest for the originality of the observations they contain. Many parts of them are admirably adapted for giving an insight into problems regarding the structure and changes of the earth's surface, and in fact they form a charming introduction to physical geology and physiography in their application to special domains. The books themselves cannot be obtained for many times the price of the present volume, and both the general reader, who desires to know more of Darwin's work, and the student of geology, who naturally wishes to know how a master mind reasoned on most important geological subjects, will be glad of the opportunity of possessing them in a convenient and cheap form....

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Plos One : Detection of Infectious Laryngotracheitis Virus by Real- Time Pcr in Naturally and Experimentally Infected Chickens, Volume 8

By: Helene F. Rosenberg

Description : Infectious laryngotracheitis (ILT) is an acute, highly contagious upper-respiratory infectious disease of chickens. In this study, a real-time PCR method was developed for fast and accurate detection and quantitation of ILTV DNA of chickens experimentally infected with ILTV strain LJS09 and naturally infected chickens. The detection lower limit of the assay was 10 copies of DNA. There were no cross reactions with the DNA and RNA of infectious bursal disease virus, chicken anemia virus, reticuloendotheliosis virus, avian reovirus, Newcastle disease virus, and Marek’s disease virus. The real-time PCR was reproducible as the coefficients of variation of reproducibility of the intra-assay and the inter-assay were less than 2%. The real-time PCR was used to detect the levels of the ILTV DNA in the tissues of specific pathogen free (SPF) chickens infected with ILTV at different times post infection. ILTV DNA was detected by real-time PCR in the heart, liver, spleen, lung, kidney, larynx, tongue, thymus, glandular stomach, duodenum, pancreatic gland, small intestine, large intestine, cecum, cecal tonsil, bursa of Fabricius, a...

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Volcanic Islands

By: Charles Darwin

Although in some respects more technical in their subjects and style than Darwin?s ?Journal,? the books here reprinted will never lose their value and interest for the originality of the observations they contain. Many parts of them are admirably adapted for giving an insight into problems regarding the structure and changes of the earth?s surface, and in fact they form a charming introduction to physical geology and physiography in their application to special domains. The books themselves cannot be obtained for many times the price of the present volume, and both the general reader, who desires to know more of Darwin?s work, and the student of geology, who naturally wishes to know how a master mind reasoned on most important geological subjects, will be glad of the opportunity of possessing them in a convenient and cheap form....

TABLE OF CONTENTS. CRITICAL INTRODUCTION. CHAPTER I.--ST. JAGO, IN THE CAPE DE VERDE ARCHIPELAGO. Rocks of the lowest series.--A calcareous sedimentary deposit, with recent shells, altered by the contact of superincumbent lava, its horizontality and extent.--Subsequent volcanic eruptions, associated with calcareous matter in an earthy and fibrous form, and often enclosed within the separate cells of the scoriae.--Ancient and obliterated orifices of eruption of small size.--Difficulty of tracing over a bare plain recent streams of lava.--Inland hills of more ancient volcanic rock.--Decomposed olivine in large masses.--Feldspathic rocks beneath the upper crystalline basaltic strata.--Uniform structure and form of the more ancient volcanic hills.--Form of the valleys near the coast.--Conglomerate now forming on the sea beach....

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Plos One : the Ubiquitin Ligase Nedd4-1 Participates in Denervation-induced Skeletal Muscle Atrophy in Mice, Volume 7

By: Richard Jay Smeyne

Description : Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging. In all these conditions, ubiquitin-dependent proteolysis is a key regulator of the loss of muscle mass, and ubiquitin ligases confer specificity to this process by interacting with, and linking ubiquitin moieties to target substrates through protein:protein interaction domains. Our previous work suggested that the ubiquitin-protein ligase Nedd4-1 is a potential mediator of skeletal muscle atrophy associated with inactivity (denervation, unloading and immobility). Here we generated a novel tool, the Nedd4-1 skeletal muscle-specific knockout mouse (myoCre:Nedd4-1flox/flox) and subjected it to a well validated model of denervation induced skeletal muscle atrophy. The absence of Nedd4-1 resulted in increased weights and cross-sectional area of type II fast twitch fibres of denervated gastrocnemius muscle compared with wild type littermates controls, at seven and fourteen days following tibial nerve tr...

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