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Plos Genetics : Functional Polymorphisms in Prodhare Associated with Risk and Protection for Schizophrenia and Fronto- Striatal Structure and Function, Volume 4

By Katsanis, Nicholas

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Book Id: WPLBN0003925976
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Functional Polymorphisms in Prodhare Associated with Risk and Protection for Schizophrenia and Fronto- Striatal Structure and Function, Volume 4  
Author: Katsanis, Nicholas
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Katsanis, N. (n.d.). Plos Genetics : Functional Polymorphisms in Prodhare Associated with Risk and Protection for Schizophrenia and Fronto- Striatal Structure and Function, Volume 4. Retrieved from http://www.worldlibrary.org/


Description
Description : PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that functional polymorphisms in PRODH are associated with schizophrenia, with protective and risk alleles having opposite effects on POX activity. Using a multimodal imaging genetics approach, we demonstrate that haplotypes constructed from these risk and protective functional polymorphisms have dissociable correlations with structure, function, and connectivity of striatum and prefrontal cortex, impacting critical circuitry implicated in the pathophysiology of schizophrenia. Specifically, the schizophrenia risk haplotype was associated with decreased striatal volume and increased striatal-frontal functional connectivity, while the protective haplotype was associated with decreased striatal-frontal functional connectivity. Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia.

 

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