World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis Elegans, Volume 7

By Ashrafi, Kaveh

Click here to view

Book Id: WPLBN0003931657
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis Elegans, Volume 7  
Author: Ashrafi, Kaveh
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Publication Date:
Publisher: Plos

Description : Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the C. elegans histidine ammonia lyase (haly-1) gene promote zinc tolerance. C. elegans haly- 1 encodes a protein that is homologous to vertebrate HAL, an enzyme that converts histidine to urocanic acid. haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. These results suggest the model that elevated histidine chelates zinc and thereby reduces zinc toxicity. Supporting this hypothesis, we demonstrated that dietary histidine promotes zinc tolerance. Nickel is another metal that binds histidine with high affinity. We demonstrated that haly-1 mutant animals are resistant to nickel toxicity and dietary histidine promotes nickel tolerance in wild-type animals. These studies identify a novel role for haly-1 and histidine in zinc metabolism and may be relevant for other animals.


Click To View

Additional Books

  • Plos Genetics : Too Much Cleavage of Cyc... (by )
  • Plos Genetics : Methylated H3K4, a Trans... (by )
  • Plos Genetics : Discovery of a Modified ... (by )
  • Plos Genetics : Dna Sequences Shaped by ... (by )
  • Plos Genetics : a Pol V–mediated Silenci... (by )
  • Plos Genetics : High-throughput Genetic ... (by )
  • Plos Genetics : Interpretation of Geneti... (by )
  • Plos Genetics : Lgl2 Executes Its Functi... (by )
  • Plos Genetics : Interferon Regulatory Fa... (by )
  • Plos Genetics : Genetic Adaptation Assoc... (by )
  • Plos Genetics : Uncoupling of Satellite ... (by )
  • Plos Genetics : Genomic Analysis of Natu... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.