World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Abt-737 Induces Bim Expression Via Jnk Signaling Pathway and Its Effect on the Radiation Sensitivity of Hela Cells, Volume 7

By Takehara, Tetsuo

Click here to view

Book Id: WPLBN0003933278
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Abt-737 Induces Bim Expression Via Jnk Signaling Pathway and Its Effect on the Radiation Sensitivity of Hela Cells, Volume 7  
Author: Takehara, Tetsuo
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Takehara, T. (n.d.). Plos One : Abt-737 Induces Bim Expression Via Jnk Signaling Pathway and Its Effect on the Radiation Sensitivity of Hela Cells, Volume 7. Retrieved from http://www.worldlibrary.org/


Description
Description : ABT-737 is a BH3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic Bcl-2 family proteins including Bcl2, Bcl-xL and Bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-Bid, Bad, Bim). In this study, we demonstrate that ABT-737 improved the radiation sensitivity of cervical cancer HeLa cells and thereby provoked cell apoptosis. Our results show that ABT-737 inhibited HeLa cell proliferation and activated JNK and its downstream target c-Jun, which caused the up-regulation of Bim expression. Blockade of JNK/c-Jun signaling pathway resulted in significant down-regulation of ABT-737-induced Bim mRNA and protein expression level. Also, ABT-737 could evoke the Bim promoter activity, and enhance the radiation sensitivity of HeLa cells via JNK/c-Jun and Bim signaling pathway. Our data imply that combination of ABT-737 and conventional radiation therapy might represent a highly effective therapeutic approach for future treatment of cervical cancer.

 

Click To View

Additional Books


  • Plos One : Self-renewal and Differentiat... (by )
  • Plos One : Characterization of the Dista... (by )
  • Plos One : Applying Reversible Mutations... (by )
  • Plos One : Biapenem Inactivation by B2 M... (by )
  • Plos One : Ethylene Response Factor 6 is... (by )
  • Plos One : Personality and Information G... (by )
  • Plos One : the Discovery of Stromatolite... (by )
  • Plos One : Near Infrared Imaging of Egfr... (by )
  • Plos One : Human Neutrophil Cytoskeletal... (by )
  • Plos One : Quantifying Morphological Par... (by )
  • Plos One : Bacteriuria Amongst Pregnant ... (by )
  • Plos One : Word Generalization by a Dog ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.