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Plos One : Mechanism-based Urinary Biomarkers to Identify the Potential for Aminoglycoside-induced Nephrotoxicity in Premature Neonates ; a Proof-of-concept Study, Volume 7

By Burdmann, Emmanuel, A.

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Book Id: WPLBN0003940495
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Reproduction Date: 2015

Title: Plos One : Mechanism-based Urinary Biomarkers to Identify the Potential for Aminoglycoside-induced Nephrotoxicity in Premature Neonates ; a Proof-of-concept Study, Volume 7  
Author: Burdmann, Emmanuel, A.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Burdmann, E. A. (n.d.). Plos One : Mechanism-based Urinary Biomarkers to Identify the Potential for Aminoglycoside-induced Nephrotoxicity in Premature Neonates ; a Proof-of-concept Study, Volume 7. Retrieved from http://www.worldlibrary.org/


Description
Description : Premature infants are frequently exposed to aminoglycoside antibiotics. Novel urinary biomarkers may provide a noninvasive means for the early identification of aminoglycoside-related proximal tubule renal toxicity, to enable adjustment of treatment and identification of infants at risk of long-term renal impairment. In this proof-of-concept study, urine samples were collected from 41 premature neonates (#32 weeks gestation) at least once per week, and daily during courses of gentamicin, and for 3 days afterwards. Significant increases were observed in the three urinary biomarkers measured (Kidney Injury Molecule-1 (KIM-1), Neutrophil Gelatinase-associated Lipocalin (NGAL), and N-acetyl-b-D-glucosaminidase (NAG)) during treatment with multiple courses of gentamicin. When adjusted for potential confounders, the treatment effect of gentamicin remained significant only for KIM-1 (mean difference from not treated, 1.35 ng/mg urinary creatinine: 95% CI 0.05–2.65). Our study shows that (a) it is possible to collect serial urine samples from premature neonates, and that (b) proximal tubule specific urinary biomarkers can act as indicators of aminoglycoside-associated nephrotoxicity in this age group. Further studies to investigate the clinical utility of novel urinary biomarkers in comparison to serum creatinine need to be undertaken.

 

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