World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : the Ubiquitin Ligase Nedd4-1 Participates in Denervation-induced Skeletal Muscle Atrophy in Mice, Volume 7

By Smeyne, Richard, Jay

Click here to view

Book Id: WPLBN0003961576
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : the Ubiquitin Ligase Nedd4-1 Participates in Denervation-induced Skeletal Muscle Atrophy in Mice, Volume 7  
Author: Smeyne, Richard, Jay
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Smeyne, R. J. (n.d.). Plos One : the Ubiquitin Ligase Nedd4-1 Participates in Denervation-induced Skeletal Muscle Atrophy in Mice, Volume 7. Retrieved from http://www.worldlibrary.org/


Description
Description : Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging. In all these conditions, ubiquitin-dependent proteolysis is a key regulator of the loss of muscle mass, and ubiquitin ligases confer specificity to this process by interacting with, and linking ubiquitin moieties to target substrates through protein:protein interaction domains. Our previous work suggested that the ubiquitin-protein ligase Nedd4-1 is a potential mediator of skeletal muscle atrophy associated with inactivity (denervation, unloading and immobility). Here we generated a novel tool, the Nedd4-1 skeletal muscle-specific knockout mouse (myoCre:Nedd4-1flox/flox) and subjected it to a well validated model of denervation induced skeletal muscle atrophy. The absence of Nedd4-1 resulted in increased weights and cross-sectional area of type II fast twitch fibres of denervated gastrocnemius muscle compared with wild type littermates controls, at seven and fourteen days following tibial nerve transection. These effects are not mediated by the Nedd4-1 substrates MTMR4, FGFR1 and Notch-1. These results demonstrate that Nedd4-1 plays an important role in mediating denervation-induced skeletal muscle atrophy in vivo.

 

Click To View

Additional Books


  • Plos One : Polymorphism of Orm1is Associ... (by )
  • Plos One : Willingness to Use the Intern... (by )
  • Plos One : Transmembrane Prostatic Acid ... (by )
  • Plos One : Functional Characterization o... (by )
  • Plos One : Preference and Performance in... (by )
  • Plos One : Fibrillin-1 Mutations Causing... (by )
  • Plos One : Ataa, a New Member of the Tri... (by )
  • Plos One : Cross-linguistic Similarity a... (by )
  • Plos One : Young Children Consider Merit... (by )
  • Plos One : Nesting Phenology of Marine T... (by )
  • Plos One : Tnni3K, a Cardiac-specific Ki... (by )
  • Plos One : Implicit and Explicit Contrib... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.