World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Requirement for Core 2 O-glycans for Optimal Resistance to Helminth Infection, Volume 8

By Sarah, C. Mullaly

Click here to view

Book Id: WPLBN0003966013
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Requirement for Core 2 O-glycans for Optimal Resistance to Helminth Infection, Volume 8  
Author: Sarah, C. Mullaly
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Description
Description : The migration of lymphocytes to the small intestine is controlled by expression of the integrin a4b7 and the chemokine receptor CCR9. However, the molecules that specifically regulate migration to the large intestine remain unclear. Immunity to infection with the large intestinal helminth parasite Trichuris muris is dependent upon CD4+ T cells that migrate to the large intestine. We examine the role of specific chemokine receptors, adhesion molecules and glycosyltransferases in the development of protective immunity to Trichuris. Mice deficient in expression of the chemokine receptors CCR2 or CCR6 were resistant to infection with Trichuris. Similarly, loss of CD34, CD43, CD44 or PSGL-1 had no effect on resistance to infection. In contrast, simultaneous deletion of the Core2 b1,6-N-acetylglucosaminyltransferase (C2GnT) enzymes C2GnT1 and C2Gnt2 resulted in delayed expulsion of worms. These results suggest that C2GnT-dependent modifications may play a role in migration of protective immune cells to the large intestine.

 

Click To View

Additional Books


  • Plos One : Intracoronary Versus Intraven... (by )
  • Plos One : Highly Efficient Isolation of... (by )
  • Plos One : the Transcriptomic Basis of O... (by )
  • Plos One : Near Infrared Imaging of Egfr... (by )
  • Plos One : Ptger4Expression-modulating P... (by )
  • Plos One : 3-d Worm Tracker for Freely M... (by )
  • Plos One : Development of Time Sensitivi... (by )
  • Plos One : Changes in Natural Foxp3+treg... (by )
  • Plos One : Metal Binding is Critical for... (by )
  • Plos One : Neonicotinoid Insecticides Al... (by )
  • Plos One : Increased Hiv Incidence in Me... (by )
  • Plos One : the Ambiguous Base-pairing an... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.